Dec 22, 2016
Prions are perhaps some of the most terrifying infectious particles known to man. But did you know that patients with some prion diseases actually shed these contagious proteins in their urine? These and other facts about prion diseases are discussed in this week's episode of BrainWaves. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. REFERENCES 1. Zabel MD and Reid C. A brief history of prions. Pathog Dis. 2015;73:ftv087. 2. Geschwind MD. Prion Diseases. Continuum (Minneap Minn). 2015;21:1612-38. 3. Rutala WA and Weber DJ. Creutzfeldt-Jakob disease: recommendations for disinfection and sterilization. Clin Infect Dis. 2001;32:1348-56. 4. Glatzel M, Abela E, Maissen M and Aguzzi A. Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. The New England journal of medicine. 2003;349:1812-20. 5. Moda F, Gambetti P, Notari S, Concha-Marambio L, Catania M, Park KW, Maderna E, Suardi S, Haik S, Brandel JP, Ironside J, Knight R, Tagliavini F and Soto C. Prions in the urine of patients with variant Creutzfeldt-Jakob disease. The New England journal of medicine. 2014;371:530-9. 6. Wieser HG, Schindler K and Zumsteg D. EEG in Creutzfeldt-Jakob disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2006;117:935-51. 7. Lapergue B, Demeret S, Denys V, Laplanche JL, Galanaud D, Verny M, Sazdovitch V, Baulac M, Haik S, Hauw JJ, Bolgert F, Brandel JP and Navarro V. Sporadic Creutzfeldt-Jakob disease mimicking nonconvulsive status epilepticus. Neurology. 2010;74:1995-9. 8. Siegler JE, Jacobs DA, Amado D, Adams JL and Berger JR. Rapidly progressive dementia with hypoglycorrhachia. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2015;22:1685-7.