Oct 1, 2020
As the second most common vascular malformation in the central
nervous system, cerebral cavernomas are often incidental
radiographic findings. Also incidental is Jim’s interest in
mediocre sci-fi television shows, such as Netflix’s recent series,
Away—which incidentally includes one character with a symptomatic
cerebral cavernoma. This week on the podcast, Dr. Siegler discusses
with Dr. Dena Little (Cooper University Hospital) the epidemiology,
clinical course, and management (including counseling) of patients
with this vascular malformation.
Plus, a critical appraisal of Away’s medical consultant. 0_o
Produced by James E. Siegler and Dena Little. Music courtesy of
Ars Sonor, Andrew Sacco, Chris Zabriskie, and Purple Planet Music.
The opening theme was composed by Jimothy Dalton. Sound effects by
Mike Koenig and Daniel Simion. Unless otherwise mentioned in the
podcast, no competing financial interests exist in the content of
this episode. BrainWaves' podcasts and online content are intended
for medical education only and should not be used for clinical
decision making. Be sure to follow us on Twitter @brainwavesaudio
for the latest updates to the podcast.
- Pozzati E, Acciarri N, Tognetti F, Marliani F and Giangaspero
F. Growth, subsequent bleeding, and de novo appearance of cerebral
cavernous angiomas. Neurosurgery. 1996;38:662-9; discussion
- Batra S, Lin D, Recinos PF, Zhang J and Rigamonti D. Cavernous
malformations: natural history, diagnosis and treatment. Nature
reviews Neurology. 2009;5:659-70.
- Gross BA, Lin N, Du R and Day AL. The natural history of
intracranial cavernous malformations. Neurosurgical focus.
- Horne MA, Flemming KD, Su IC, Stapf C, Jeon JP, Li D, Maxwell
SS, White P, Christianson TJ, Agid R, Cho WS, Oh CW, Wu Z, Zhang
JT, Kim JE, Ter Brugge K, Willinsky R, Brown RD, Jr., Murray GD,
Al-Shahi Salman R and Cerebral Cavernous Malformations Individual
Patient Data Meta-analysis C. Clinical course of untreated cerebral
cavernous malformations: a meta-analysis of individual patient
data. The Lancet Neurology. 2016;15:166-173.
- Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL,
Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H and
Morrison L. Familial Cerebral Cavernous Malformations. Stroke; a
journal of cerebral circulation. 2019;50:1294-1301.
- Zuurbier SM, Hickman CR, Tolias CS, Rinkel LA, Leyrer R,
Flemming KD, Bervini D, Lanzino G, Wityk RJ, Schneble HM, Sure U,
Al-Shahi Salman R and Scottish Audit of Intracranial Vascular
Malformations Steering C. Long-term antithrombotic therapy and risk
of intracranial haemorrhage from cerebral cavernous malformations:
a population-based cohort study, systematic review, and
meta-analysis. The Lancet Neurology. 2019;18:935-941.