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BrainWaves: A Neurology Podcast

Jul 11, 2019

In this week's Teaching through Clinical Cases, Dr. Olga Rosenveld Thon (Drexel) walks us through the challenging management decisions that emerge in the care of women with demyelinating disease. Why are women prone to multiple sclerosis? How do pregnancy, breastfeeding, and menopause influence the disease course--and should these events alter the course of their therapy?

Produced by James E. Siegler and Olga Thon. Music courtesy of Cellophane Sam, Chris Zabriskie, Jon Watts, Kai Engel, and Lee Rosevere. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast.


Dr. Rosenveld Thon reports relevant financial interests in Ocrevus, as a consultant.


  1. Michel L, Foucher Y, Vukusic S, Confavreux C, de Seze J, Brassat D, Clanet M, Clavelou P, Ouallet JC, Brochet B, Pelletier J, Labauge P, Lebrun C, Lepage E, Le Frere F, Jacq-Foucher M, Barriere P, Wiertlewski S, Laplaud DA and Club Francophone de la Sclerose En P. Increased risk of multiple sclerosis relapse after in vitro fertilisation. Journal of neurology, neurosurgery, and psychiatry. 2012;83:796-802.
  2. Nielsen NM, Westergaard T, Rostgaard K, Frisch M, Hjalgrim H, Wohlfahrt J, Koch-Henriksen N and Melbye M. Familial risk of multiple sclerosis: a nationwide cohort study. American journal of epidemiology. 2005;162:774-8.
  3. Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P and Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. The New England journal of medicine. 1998;339:285-91.
  4. Bove R and Chitnis T. The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis. Multiple sclerosis. 2014;20:520-6.
  5. Bove R. Women's Issues in Multiple Sclerosis. Semin Neurol. 2016;36:154-62.
  6. Rankin K and Bove R. Caring for Women with Multiple Sclerosis Across the Lifespan. Current neurology and neuroscience reports. 2018;18:36.
  7. Ramagopalan SV, Dobson R, Meier UC and Giovannoni G. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. The Lancet Neurology. 2010;9:727-39.
  8. Correale J, Farez MF and Ysrraelit MC. Increase in multiple sclerosis activity after assisted reproduction technology. Annals of neurology. 2012;72:682-94.
  9. Bove R, Chitnis T and Houtchens M. Menopause in multiple sclerosis: therapeutic considerations. Journal of neurology. 2014;261:1257-68.